Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis

William R. Leonard, Kevin M. Belyk, Dean R. Bender, David A. Conlon, David L. Hughes, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

(Equation presented) The relative and absolute configuration of the pneumocandin B0 side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.

Original languageEnglish (US)
Pages (from-to)4201-4204
Number of pages4
JournalOrganic Letters
Volume4
Issue number24
DOIs
StatePublished - Nov 28 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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