Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis

William R. Leonard; Kevin M. Belyk; Dean R. Bender; David A. Conlon; David L. Hughes; Paul J. Reider

doi:10.1021/ol0261940

Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B₀ by asymmetric synthesis

William R. Leonard, Kevin M. Belyk, Dean R. Bender, David A. Conlon, David L. Hughes, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

(Equation presented) The relative and absolute configuration of the pneumocandin B₀ side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.

Original language	English (US)
Pages (from-to)	4201-4204
Number of pages	4
Journal	Organic letters
Volume	4
Issue number	24
DOIs	https://doi.org/10.1021/ol0261940
State	Published - Nov 28 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0261940

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title = "Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis",

abstract = "(Equation presented) The relative and absolute configuration of the pneumocandin B0 side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.",

author = "Leonard, {William R.} and Belyk, {Kevin M.} and Bender, {Dean R.} and Conlon, {David A.} and Hughes, {David L.} and Reider, {Paul J.}",

year = "2002",

month = nov,

day = "28",

doi = "10.1021/ol0261940",

language = "English (US)",

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journal = "Organic letters",

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T1 - Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis

AU - Leonard, William R.

AU - Belyk, Kevin M.

AU - Bender, Dean R.

AU - Conlon, David A.

AU - Hughes, David L.

AU - Reider, Paul J.

PY - 2002/11/28

Y1 - 2002/11/28

N2 - (Equation presented) The relative and absolute configuration of the pneumocandin B0 side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.

AB - (Equation presented) The relative and absolute configuration of the pneumocandin B0 side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.

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U2 - 10.1021/ol0261940

DO - 10.1021/ol0261940

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AN - SCOPUS:0037191611

SN - 1523-7060

VL - 4

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EP - 4204

JO - Organic letters

JF - Organic letters

IS - 24

ER -

Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B₀ by asymmetric synthesis

Abstract

All Science Journal Classification (ASJC) codes

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