Determinants of hepatitis B and delta virus host tropism

Benjamin Y. Winer; Alexander Ploss

doi:10.1016/j.coviro.2015.06.004

Determinants of hepatitis B and delta virus host tropism

Benjamin Y. Winer, Alexander Ploss

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Hepatitis B virus (HBV) infections are a global health problem afflicting approximately 360 million patients. Of these individuals, 15-20 million are co-infected with hepatitis delta virus (HDV). Progress toward curative therapies has been impeded by the highly restricted host tropism of HBV, which is limited to productive infections in humans and chimpanzees. Here, we will discuss different approaches that have been taken to study HBV and HDV infections in vivo. The development of transgenic and humanized mice has lead to deeper insights into HBV pathogenesis. An improved understanding of the determinants governing HBV and HDV species tropism will aid in the construction of a small animal model with inheritable susceptible to HBV/HDV.

Original language	English (US)
Pages (from-to)	109-116
Number of pages	8
Journal	Current Opinion in Virology
Volume	13
DOIs	https://doi.org/10.1016/j.coviro.2015.06.004
State	Published - Aug 2015

All Science Journal Classification (ASJC) codes

Virology

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10.1016/j.coviro.2015.06.004

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title = "Determinants of hepatitis B and delta virus host tropism",

abstract = "Hepatitis B virus (HBV) infections are a global health problem afflicting approximately 360 million patients. Of these individuals, 15-20 million are co-infected with hepatitis delta virus (HDV). Progress toward curative therapies has been impeded by the highly restricted host tropism of HBV, which is limited to productive infections in humans and chimpanzees. Here, we will discuss different approaches that have been taken to study HBV and HDV infections in vivo. The development of transgenic and humanized mice has lead to deeper insights into HBV pathogenesis. An improved understanding of the determinants governing HBV and HDV species tropism will aid in the construction of a small animal model with inheritable susceptible to HBV/HDV.",

author = "Winer, {Benjamin Y.} and Alexander Ploss",

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year = "2015",

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doi = "10.1016/j.coviro.2015.06.004",

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AU - Ploss, Alexander

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AB - Hepatitis B virus (HBV) infections are a global health problem afflicting approximately 360 million patients. Of these individuals, 15-20 million are co-infected with hepatitis delta virus (HDV). Progress toward curative therapies has been impeded by the highly restricted host tropism of HBV, which is limited to productive infections in humans and chimpanzees. Here, we will discuss different approaches that have been taken to study HBV and HDV infections in vivo. The development of transgenic and humanized mice has lead to deeper insights into HBV pathogenesis. An improved understanding of the determinants governing HBV and HDV species tropism will aid in the construction of a small animal model with inheritable susceptible to HBV/HDV.

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DO - 10.1016/j.coviro.2015.06.004

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AN - SCOPUS:84948701540

SN - 1879-6257

VL - 13

SP - 109

EP - 116

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

Determinants of hepatitis B and delta virus host tropism

Abstract

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