Detection of biogenic CO production above vascular cell cultures using a near-room-temperature QC-DFB laser

A. A. Kosterev, F. K. Tittel, W. Durante, M. Allen, R. Köhler, C. Gmachl, F. Capasso, D. L. Sivco, A. Y. Cho

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

We report the first application of pulsed, near-room-temperature quantum cascade laser technology to the continuous detection of biogenic CO production rates above viable cultures of vascular smooth muscle cells. A computer-controlled sequence of measurements over a 9-h period was obtained, resulting in a minimum detectable CO production of 20 ppb in a 1-m optical path above a standard cell-culture flask. Data-processing procedures for real-time monitoring of both biogenic and ambient atmospheric CO concentrations are described.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalApplied Physics B: Lasers and Optics
Volume74
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

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