Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Yakir A. Reshef, Hilary K. Finucane, David R. Kelley, Alexander Gusev, Dylan Kotliar, Jacob C. Ulirsch, Farhad Hormozdiari, Joseph Nasser, Luke O’Connor, Bryce van de Geijn, Po Ru Loh, Sharon R. Grossman, Gaurav Bhatia, Steven Gazal, Pier Francesco Palamara, Luca Pinello, Nick Patterson, Ryan P. Adams, Alkes L. Price