Designed double-strand DNA cleavage with chelate-appended porphyrins

John Taylor Groves, Akio Matsunaga

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal complexing appendages, were shown to mediate the oxidative double-strand cleavage of pBR322 plasmid DNA. By contrast, a porphyrin with one appendage was found to mediate only single-strand breaks.

Original languageEnglish (US)
Pages (from-to)1595-1600
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number13
DOIs
StatePublished - Jul 9 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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