Designed double-strand DNA cleavage with chelate-appended porphyrins

John Taylor Groves; Akio Matsunaga

doi:10.1016/S0960-894X(96)00281-8

Designed double-strand DNA cleavage with chelate-appended porphyrins

John Taylor Groves, Akio Matsunaga

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Abstract

The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal complexing appendages, were shown to mediate the oxidative double-strand cleavage of pBR322 plasmid DNA. By contrast, a porphyrin with one appendage was found to mediate only single-strand breaks.

Original language	English (US)
Pages (from-to)	1595-1600
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(96)00281-8
State	Published - Jul 9 1996

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(96)00281-8

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title = "Designed double-strand DNA cleavage with chelate-appended porphyrins",

abstract = "The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal complexing appendages, were shown to mediate the oxidative double-strand cleavage of pBR322 plasmid DNA. By contrast, a porphyrin with one appendage was found to mediate only single-strand breaks.",

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AU - Matsunaga, Akio

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N2 - The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal complexing appendages, were shown to mediate the oxidative double-strand cleavage of pBR322 plasmid DNA. By contrast, a porphyrin with one appendage was found to mediate only single-strand breaks.

AB - The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal complexing appendages, were shown to mediate the oxidative double-strand cleavage of pBR322 plasmid DNA. By contrast, a porphyrin with one appendage was found to mediate only single-strand breaks.

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DO - 10.1016/S0960-894X(96)00281-8

M3 - Article

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Designed double-strand DNA cleavage with chelate-appended porphyrins

Abstract

All Science Journal Classification (ASJC) codes

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