Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors

Robert E. Babine; Nan Zhang; Steven R. Schow; Zhangbao Xu; Randal A. Byrn; Richard C. Hastings; M. F. Semmelhack; Michael M. Wick; Suresh S. Kerwar

doi:10.1016/S0960-894X(01)80159-1

Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors

Robert E. Babine
, Nan Zhang
, Steven R. Schow
, Zhangbao Xu
, Randal A. Byrn
, Richard C. Hastings
, M. F. Semmelhack
, Michael M. Wick
, Suresh S. Kerwar

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.

Original language	English (US)
Pages (from-to)	583-588
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(01)80159-1
State	Published - Feb 24 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)80159-1

Cite this

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title = "Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors",

abstract = "A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.",

author = "Babine, \{Robert E.\} and Nan Zhang and Schow, \{Steven R.\} and Zhangbao Xu and Byrn, \{Randal A.\} and Hastings, \{Richard C.\} and Semmelhack, \{M. F.\} and Wick, \{Michael M.\} and Kerwar, \{Suresh S.\}",

year = "1994",

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doi = "10.1016/S0960-894X(01)80159-1",

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T1 - Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors

AU - Babine, Robert E.

AU - Zhang, Nan

AU - Schow, Steven R.

AU - Xu, Zhangbao

AU - Byrn, Randal A.

AU - Hastings, Richard C.

AU - Semmelhack, M. F.

AU - Wick, Michael M.

AU - Kerwar, Suresh S.

PY - 1994/2/24

Y1 - 1994/2/24

N2 - A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.

AB - A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.

UR - https://www.scopus.com/pages/publications/0028261775

UR - https://www.scopus.com/pages/publications/0028261775#tab=citedBy

U2 - 10.1016/S0960-894X(01)80159-1

DO - 10.1016/S0960-894X(01)80159-1

M3 - Article

AN - SCOPUS:0028261775

SN - 0960-894X

VL - 4

SP - 583

EP - 588

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors

Abstract

All Science Journal Classification (ASJC) codes

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