Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors

Robert E. Babine, Nan Zhang, Steven R. Schow, Zhangbao Xu, Randal A. Byrn, Richard C. Hastings, M. F. Semmelhack, Michael M. Wick, Suresh S. Kerwar

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.

Original languageEnglish (US)
Pages (from-to)583-588
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number4
DOIs
StatePublished - Feb 24 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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