TY - GEN
T1 - Design of an optofluidic device for the measurement of the elastic modulus of deformable particles
AU - Villone, Massimiliano M.
AU - Nunes, Janine K.
AU - Li, Yankai
AU - Stone, Howard A.
AU - Maffettone, Pier Luca
N1 - Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2019
Y1 - 2019
N2 - Suspensions carrying deformable inclusions are ubiquitous in nature and applications. Hence, high-throughput characterization of the mechanical properties of soft particles is of great interest. Recently, a non-invasive optofluidic technique has been developed for the measurement of the interfacial tension between two immiscible liquids.1, 2 We adapt such technique to the case of soft solid beads, thus designing a non-invasive optofluidic device for the measurement of the mechanical properties of deformable particles from real-time optical imaging of their deformation. The device consists of a cylindrical microfluidic channel with a cross-section reduction in which we make initially spherical soft beads flow suspended in a Newtonian carrier. By imaging the deformation of a particle in real time while it goes through the constriction, it is possible to get a measure of its elastic modulus through a theoretically derived-correlation. We provide both experimental and numerical validation of our device.
AB - Suspensions carrying deformable inclusions are ubiquitous in nature and applications. Hence, high-throughput characterization of the mechanical properties of soft particles is of great interest. Recently, a non-invasive optofluidic technique has been developed for the measurement of the interfacial tension between two immiscible liquids.1, 2 We adapt such technique to the case of soft solid beads, thus designing a non-invasive optofluidic device for the measurement of the mechanical properties of deformable particles from real-time optical imaging of their deformation. The device consists of a cylindrical microfluidic channel with a cross-section reduction in which we make initially spherical soft beads flow suspended in a Newtonian carrier. By imaging the deformation of a particle in real time while it goes through the constriction, it is possible to get a measure of its elastic modulus through a theoretically derived-correlation. We provide both experimental and numerical validation of our device.
KW - Deformable particles
KW - Mechanical properties
KW - Optofluidics
UR - http://www.scopus.com/inward/record.url?scp=85072644408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072644408&partnerID=8YFLogxK
U2 - 10.1117/12.2524901
DO - 10.1117/12.2524901
M3 - Conference contribution
AN - SCOPUS:85072644408
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV
A2 - Ferraro, Pietro
A2 - Grilli, Simonetta
A2 - Ritsch-Marte, Monika
A2 - Ritsch-Marte, Monika
A2 - Hitzenberger, Christoph K.
PB - SPIE
T2 - Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV 2019
Y2 - 24 June 2019 through 26 June 2019
ER -