Design of an optofluidic device for the measurement of the elastic modulus of deformable particles

Massimiliano M. Villone, Janine K. Nunes, Yankai Li, Howard A. Stone, Pier Luca Maffettone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Suspensions carrying deformable inclusions are ubiquitous in nature and applications. Hence, high-throughput characterization of the mechanical properties of soft particles is of great interest. Recently, a non-invasive optofluidic technique has been developed for the measurement of the interfacial tension between two immiscible liquids.1, 2 We adapt such technique to the case of soft solid beads, thus designing a non-invasive optofluidic device for the measurement of the mechanical properties of deformable particles from real-time optical imaging of their deformation. The device consists of a cylindrical microfluidic channel with a cross-section reduction in which we make initially spherical soft beads flow suspended in a Newtonian carrier. By imaging the deformation of a particle in real time while it goes through the constriction, it is possible to get a measure of its elastic modulus through a theoretically derived-correlation. We provide both experimental and numerical validation of our device.

Original languageEnglish (US)
Title of host publicationOptical Methods for Inspection, Characterization, and Imaging of Biomaterials IV
EditorsPietro Ferraro, Simonetta Grilli, Monika Ritsch-Marte, Monika Ritsch-Marte, Christoph K. Hitzenberger
PublisherSPIE
ISBN (Electronic)9781510627994
DOIs
StatePublished - 2019
EventOptical Methods for Inspection, Characterization, and Imaging of Biomaterials IV 2019 - Munich, Germany
Duration: Jun 24 2019Jun 26 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11060
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceOptical Methods for Inspection, Characterization, and Imaging of Biomaterials IV 2019
CountryGermany
CityMunich
Period6/24/196/26/19

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Keywords

  • Deformable particles
  • Mechanical properties
  • Optofluidics

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  • Cite this

    Villone, M. M., Nunes, J. K., Li, Y., Stone, H. A., & Maffettone, P. L. (2019). Design of an optofluidic device for the measurement of the elastic modulus of deformable particles. In P. Ferraro, S. Grilli, M. Ritsch-Marte, M. Ritsch-Marte, & C. K. Hitzenberger (Eds.), Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV [110600L] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11060). SPIE. https://doi.org/10.1117/12.2524901