Abstract
Flash NanoPrecipitation is a scalable approach to generate polymeric nanoparticles using rapid micromixing in specially designed geometries such as a confined impinging jets mixer or a Multi-Inlet Vortex Mixer (MIVM). A major limitation of formulation screening using the MIVM is that a single run requires tens of milligrams of the therapeutic. To overcome this, we have developed a scaled-down version of the MIVM, requiring as little as 0.2 mg of therapeutic, for formulation screening. The redesigned mixer can then be attached to pumps for scale-up of the identified formulation. It was shown that Reynolds number allowed accurate scaling between the 2 MIVM designs. The utility of the small-scale MIVM for formulation development was demonstrated through the encapsulation of a number of hydrophilic macromolecules using inverse Flash NanoPrecipitation with target loadings as high as 50% by mass.
Original language | English (US) |
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Pages (from-to) | 2465-2471 |
Number of pages | 7 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 107 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2018 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
Keywords
- formulation
- mixing
- nanoparticles
- particle size
- peptide delivery
- polymeric drug carrier
- protein delivery