TY - JOUR
T1 - Design of a microfluidic device for the measurement of the elastic modulus of deformable particles
AU - Villone, Massimiliano M.
AU - Nunes, Janine K.
AU - Li, Yankai
AU - Stone, Howard A.
AU - Maffettone, Pier Luca
N1 - Funding Information:
MMV thanks Patrick D. Anderson and Martien A. Hulsen, Eindhoven University of Technology, and Antonio Perazzo, Princeton University, for fruitful discussion. JKN and HAS thank the National Science Foundation (CMMI-1661672). We thank Barry Runner, SEAS Machine Shop, for CNC micro-milling and Jiang Li, University of Science and Technology, Beijing, for nanoindentation measurements.
PY - 2019
Y1 - 2019
N2 - A microfluidic technique recently proposed in the literature to measure the interfacial tension between a liquid droplet and an immiscible suspending liquid [Hudson et al., Appl. Phys. Lett., 2005, 87, 081905], [Cabral and Hudson, Lab Chip, 2006, 6, 427] is suitably adapted to the characterization of the elastic modulus of soft particles in a continuous-flow process. A microfluidic device consisting of a cylindrical pipe with a reduction in cross-section is designed, and the deformation and velocity of incompressible elastic particles suspended in a Newtonian liquid are tracked as they move along the centerline through the constriction. Kinematic and shape information is exploited to calculate the particle's elastic modulus by means of the theory of elastic particle deformation in extensional flow. The approach is validated for different orders of magnitude of the elastic capillary number through experiments and numerical simulations.
AB - A microfluidic technique recently proposed in the literature to measure the interfacial tension between a liquid droplet and an immiscible suspending liquid [Hudson et al., Appl. Phys. Lett., 2005, 87, 081905], [Cabral and Hudson, Lab Chip, 2006, 6, 427] is suitably adapted to the characterization of the elastic modulus of soft particles in a continuous-flow process. A microfluidic device consisting of a cylindrical pipe with a reduction in cross-section is designed, and the deformation and velocity of incompressible elastic particles suspended in a Newtonian liquid are tracked as they move along the centerline through the constriction. Kinematic and shape information is exploited to calculate the particle's elastic modulus by means of the theory of elastic particle deformation in extensional flow. The approach is validated for different orders of magnitude of the elastic capillary number through experiments and numerical simulations.
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U2 - 10.1039/c8sm02272k
DO - 10.1039/c8sm02272k
M3 - Article
C2 - 30601566
AN - SCOPUS:85060950985
SN - 1744-683X
VL - 15
SP - 880
EP - 889
JO - Soft Matter
JF - Soft Matter
IS - 5
ER -