Design and synthesis of molecular scaffolds with anti-infective activity

Junjia Liu, T. Aaron Bedell, Julian G. West, Erik J. Sorensen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The discovery and development of new anti-infectives is an important contemporary challenge to modern society. This challenge must be met with matching creativity and enthusiasm by chemists to avoid losing the battle with emerging strains of drug-resistant microbes. A series of case studies from our lab are presented, demonstrating our continued efforts in the areas of synthetic design, total synthesis of natural products, structure revision, and bioactive scaffold diversification. Together, these are used to highlight the power and utility of chemical synthesis to uniquely address challenges in the discovery and development of novel antibiotic compounds, particularly within the context of natural products scaffolds.

Original languageEnglish (US)
Pages (from-to)3579-3592
Number of pages14
JournalTetrahedron
Volume72
Issue number25
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Anti-infectives
  • Antibiotics
  • Diels–Alder
  • Diversification
  • MRSA
  • Mycobacterium tuberculosis
  • Natural products
  • Synthesis
  • Synthetic design
  • Total synthesis

Fingerprint Dive into the research topics of 'Design and synthesis of molecular scaffolds with anti-infective activity'. Together they form a unique fingerprint.

  • Cite this