Abstract
The discovery and development of new anti-infectives is an important contemporary challenge to modern society. This challenge must be met with matching creativity and enthusiasm by chemists to avoid losing the battle with emerging strains of drug-resistant microbes. A series of case studies from our lab are presented, demonstrating our continued efforts in the areas of synthetic design, total synthesis of natural products, structure revision, and bioactive scaffold diversification. Together, these are used to highlight the power and utility of chemical synthesis to uniquely address challenges in the discovery and development of novel antibiotic compounds, particularly within the context of natural products scaffolds.
Original language | English (US) |
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Pages (from-to) | 3579-3592 |
Number of pages | 14 |
Journal | Tetrahedron |
Volume | 72 |
Issue number | 25 |
DOIs | |
State | Published - 2016 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Keywords
- Anti-infectives
- Antibiotics
- Diels–Alder
- Diversification
- MRSA
- Mycobacterium tuberculosis
- Natural products
- Synthesis
- Synthetic design
- Total synthesis