TY - JOUR
T1 - Depression
T2 - The brain finally gets into the act
AU - Jacobs, Barry L.
N1 - Funding Information:
I thank Diane Ruble for helpful comments on an earlier draft of this manuscript. Preparation of this manuscript was supported by Grant MH 23433 from the National Institute of Mental Health.
PY - 2004/6
Y1 - 2004/6
N2 - The theory of clinical depression presented here integrates etiological factors, changes in specific structural and cellular substrates, ensuing symptomatology, and treatment and prevention. According to this theory, important etiological factors, such as stress, can suppress the production of new neurons in the adult human brain, thereby precipitating or maintaining a depressive episode. Most current treatments for depression are known to elevate brain serotonin neurotransmission, and such increases in serotonin have been shown to significantly augment the ongoing rate of neurogenesis, providing the neural substrate for new cognitions to be formed, and thereby facilitating recovery from the depressive episode. This theory also points to treatments that augment neurogenesis as new therapeutic opportunities.
AB - The theory of clinical depression presented here integrates etiological factors, changes in specific structural and cellular substrates, ensuing symptomatology, and treatment and prevention. According to this theory, important etiological factors, such as stress, can suppress the production of new neurons in the adult human brain, thereby precipitating or maintaining a depressive episode. Most current treatments for depression are known to elevate brain serotonin neurotransmission, and such increases in serotonin have been shown to significantly augment the ongoing rate of neurogenesis, providing the neural substrate for new cognitions to be formed, and thereby facilitating recovery from the depressive episode. This theory also points to treatments that augment neurogenesis as new therapeutic opportunities.
KW - Adult brain neurogenesis
KW - Clinical depression
KW - Serotonin
KW - Stress
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U2 - 10.1111/j.0963-7214.2004.00284.x
DO - 10.1111/j.0963-7214.2004.00284.x
M3 - Article
AN - SCOPUS:2942655389
SN - 0963-7214
VL - 13
SP - 103
EP - 106
JO - Current Directions in Psychological Science
JF - Current Directions in Psychological Science
IS - 3
ER -