Delayed suppression of hippocampal cell proliferation in rats following inescapable shocks

Casimir A. Fornal, Joanne Stevens, Jessica R. Barson, Gregory G. Blakley, Patricia Patterson-Buckendahl, Barry L. Jacobs

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Adult Sprague-Dawley rats were exposed to a single session of 100 inescapable tail shocks (IS). Bromodeoxyuridine (BrdU) was administered 1 h, 2 days or 7 days later and hippocampal cell proliferation (CP) was assessed after a 2-h survival period. Measures of plasma corticosterone (CORT) levels were also obtained. Despite a large increase in CORT immediately following IS, no associated change in CP was observed. In fact, the only significant change in CP was seen 7 days after IS, at a time when CORT was unchanged from control levels. These data raise questions about the general nature of the relationship between CORT and CP. They also suggest that, under some conditions, changes in hippocampal CP may emerge only after an "incubation period".

Original languageEnglish (US)
Pages (from-to)48-53
Number of pages6
JournalBrain Research
Volume1130
Issue number1
DOIs
StatePublished - Jan 26 2007

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • BrdU
  • Corticosterone
  • Dentate gyrus
  • Neurogenesis
  • Rat
  • Stress

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