Dehydroepiandrosterone Sulfate (DHEAS) and Risk for Mortality Among Older Taiwanese

Dana A. Glei, Noreen Goldman

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose: Studies based on Western populations showed a negative relationship between dehydroepiandrosterone sulfate (DHEAS) level and mortality, but no study examined this relationship in a non-Western country. We use data from a large, nationally representative sample (n = 963) of older Taiwanese to investigate whether serum DHEAS, predicts subsequent mortality during a 3-year period (2000 to 2003) and whether an effect remains after controlling for baseline health status. Methods: Baseline data collection included an individual interview, physical examination, and blood sample. A logit model is used to test the relationship between DHEAS level and risk for mortality, controlling for age, sex, and smoking status. Results: Results show a marginally significant inverse relationship between DHEAS level and 3-year mortality risk. Participants with low DHEAS levels (<54.5 μg/dL) have 64% greater odds of dying than those with higher DHEAS levels (p < 0.06). After adjusting for various indicators of health status in 2000, the odds ratio (OR) for low DHEAS level remains substantial (OR = 1.41), but not statistically significant. Conclusions: Although the analysis is limited by the short follow-up and small number of deaths, results are consistent with the notion that DHEAS level has a sizeable effect on mortality.

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalAnnals of Epidemiology
Issue number7
StatePublished - Jul 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology


  • Aged
  • Dehydroepiandrosterone
  • Dehydroepiandrosterone Sulfate
  • Elderly
  • Health Status
  • Morbidity
  • Mortality
  • Taiwan


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