Definition of the boundaries of the origin of DNA replication in simian virus 40

Kiranur N. Subramanian; Thomas Shenk

doi:10.1093/nar/5.10.3635

Definition of the boundaries of the origin of DNA replication in simian virus 40

Kiranur N. Subramanian
, Thomas Shenk

Molecular Biology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We have determined by use of DNA sequencing techniques the exact location of the deletion in dl 892, a viable deletion mutant of Simian virus 40 (sV40) reported to map very near the unique replication origin or SV40. With the help of this localization we have narrowed down the boundaries of the replication origin to 85 nucleotides within the sequence of SV40.

Original language	English (US)
Pages (from-to)	3635-3642
Number of pages	8
Journal	Nucleic acids research
Volume	5
Issue number	10
DOIs	https://doi.org/10.1093/nar/5.10.3635
State	Published - Oct 1978

All Science Journal Classification (ASJC) codes

Genetics

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10.1093/nar/5.10.3635

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title = "Definition of the boundaries of the origin of DNA replication in simian virus 40",

abstract = "We have determined by use of DNA sequencing techniques the exact location of the deletion in dl 892, a viable deletion mutant of Simian virus 40 (sV40) reported to map very near the unique replication origin or SV40. With the help of this localization we have narrowed down the boundaries of the replication origin to 85 nucleotides within the sequence of SV40.",

author = "Subramanian, \{Kiranur N.\} and Thomas Shenk",

note = "Funding Information: Acknow1edqment This research was supported by grants from the University of Illinois (GRSG and Campus Research Board) and the American Cancer Society (\#NP-248) to K.N.S. and by a grant from the National Cancer Institute (CA-19151) to T,S. Preliminary characterization of d\textbackslash{}\_ 892 by transcription to RNA and fingerprint analysis (not reported here) was done while K.N.S. was at Yale University in the laboratory of S.M. Weissman. This work was carried out during the tenure of an Established Investigatorship (to T.S.) of the American Heart Association.",

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T1 - Definition of the boundaries of the origin of DNA replication in simian virus 40

AU - Subramanian, Kiranur N.

AU - Shenk, Thomas

N1 - Funding Information: Acknow1edqment This research was supported by grants from the University of Illinois (GRSG and Campus Research Board) and the American Cancer Society (#NP-248) to K.N.S. and by a grant from the National Cancer Institute (CA-19151) to T,S. Preliminary characterization of d\_ 892 by transcription to RNA and fingerprint analysis (not reported here) was done while K.N.S. was at Yale University in the laboratory of S.M. Weissman. This work was carried out during the tenure of an Established Investigatorship (to T.S.) of the American Heart Association.

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N2 - We have determined by use of DNA sequencing techniques the exact location of the deletion in dl 892, a viable deletion mutant of Simian virus 40 (sV40) reported to map very near the unique replication origin or SV40. With the help of this localization we have narrowed down the boundaries of the replication origin to 85 nucleotides within the sequence of SV40.

AB - We have determined by use of DNA sequencing techniques the exact location of the deletion in dl 892, a viable deletion mutant of Simian virus 40 (sV40) reported to map very near the unique replication origin or SV40. With the help of this localization we have narrowed down the boundaries of the replication origin to 85 nucleotides within the sequence of SV40.

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JO - Nucleic acids research

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Definition of the boundaries of the origin of DNA replication in simian virus 40

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