Defective-interfering particles of Sindbis virus II. Homologous interference

Thomas E. Shenk, Victor Stollar

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A fraction containing defective-interfering particles of Sindbis virus was isolated by equilibrium density centrifugation of Sindbis virus stocks prepared by serial, undiluted passage through BHK-21 cells. This fraction had a mean density of 1.22 g/cc and interfered with the yield of Sindbis virus to a much greater extent than with Eastern equine encephalitis virus. Interfering activity was not limited to the 1.22 g/cc region, but extended through to the 1.20 g/cc fractions of the equilibrium density gradients.

Original languageEnglish (US)
Pages (from-to)530-534
Number of pages5
Issue number2
StatePublished - Oct 1973

All Science Journal Classification (ASJC) codes

  • Virology


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