Deep mutational scanning reveals the functional constraints and evolutionary potential of the influenza A virus PB1 protein

Immunology and Microbiology

• Influenza 100%
• Influenza Virus 100%
• Influenzavirus A 100%
• RNA-dependent RNA Polymerase 75%
• Amino Acid Substitution 75%
• Virus Evolution 50%
• Influenza A Virus (H1N1) 50%
• Host Range 25%
• Viral Replication 25%
• Drug Resistance 25%
• Protein Interaction 25%
• Mutation Rate 25%
• Antigenic Drift 25%

Biochemistry, Genetics and Molecular Biology

• Polymerase 100%
• Influenza A Virus 100%
• Influenza Virus 36%
• RNA-dependent RNA Polymerase 27%
• Amino Acid Substitution 27%
• Influenza A Virus (H1N1) 18%
• RNA 9%
• Virus Replication 9%
• Protein Interaction 9%
• Drug Resistance 9%
• Mutation Rate 9%
• Host Range 9%

Keyphrases

• Host Range Expansion 12%
• Resistance Drift 12%
• Mutational Tolerance 12%
• Replication Fitness 12%