@article{6570a1da86ec436d8913208941458624,
title = "Decoding type I and III interferon signalling during viral infection",
abstract = "Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.",
author = "Mesev, {Emily V.} and LeDesma, {Robert A.} and Alexander Ploss",
note = "Funding Information: We thank J. Gaska, F. Douam and other members of the Ploss lab, as well as A. Goglia, J. Toettcher and other members of the Toettcher lab at Princeton University for providing critical feedback on this manuscript. We apologize to all of our colleagues whose work we were unable to include or discuss due to space constraints. Work in the lab was supported by grants from the National Institutes of Health (R01 AI138797 and R01AI107301 both to A.P.), a Research Scholar Award from the American Cancer Society (RSG-15-048-01-MPC to A.P.), a Burroughs Wellcome Fund Award for Investigators in Pathogenesis (to A.P.), the New Jersey Health Foundation (to A.P.), a grant from the US Department of Defense (W81XWH18{\textquoteright}10237 to A.P.) and funding from Princeton University. E.M. and R.L. were supported by the National Institute of General Medicine Sciences of the National Institutes of Health (grant no. T32GM007388). R.L. is a recipient of a predoctoral fellowship from the National Science Foundation. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2019",
month = jun,
day = "1",
doi = "10.1038/s41564-019-0421-x",
language = "English (US)",
volume = "4",
pages = "914--924",
journal = "Nature Microbiology",
issn = "2058-5276",
publisher = "Nature Publishing Group",
number = "6",
}