Decoding type I and III interferon signalling during viral infection

Emily V. Mesev, Robert A. LeDesma, Alexander Ploss

Research output: Contribution to journalReview articlepeer-review

293 Scopus citations


Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.

Original languageEnglish (US)
Pages (from-to)914-924
Number of pages11
JournalNature Microbiology
Issue number6
StatePublished - Jun 1 2019

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology
  • Microbiology (medical)
  • Genetics
  • Cell Biology
  • Microbiology
  • Immunology


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