TY - JOUR
T1 - Decoding the Role of Temperature in RNA Virus Infections
AU - Bisht, Karishma
AU - te Velthuis, Aartjan J.W.
N1 - Publisher Copyright:
Copyright © 2022 Bisht and te Velthuis.
PY - 2022/9
Y1 - 2022/9
N2 - RNA viruses include respiratory viruses, such as coronaviruses and influenza viruses, as well as vector-borne viruses, like dengue and West Nile virus. RNA viruses like these encounter various environments when they copy themselves and spread from cell to cell or host to host. Ex vivo differences, such as geographical location and humidity, affect their stability and transmission, while in vivo differences, such as pH and host gene expression, impact viral receptor binding, viral replication, and the host immune response against the viral infection. A critical factor affecting RNA viruses both ex vivo and in vivo, and defining the outcome of viral infections and the direction of viral evolution, is temperature. In this minireview, we discuss the impact of temperature on viral replication, stability, transmission, and adaptation, as well as the host innate immune response. Improving our understanding of how RNA viruses function, survive, and spread at different temperatures will improve our models of viral replication and transmission risk analyses.
AB - RNA viruses include respiratory viruses, such as coronaviruses and influenza viruses, as well as vector-borne viruses, like dengue and West Nile virus. RNA viruses like these encounter various environments when they copy themselves and spread from cell to cell or host to host. Ex vivo differences, such as geographical location and humidity, affect their stability and transmission, while in vivo differences, such as pH and host gene expression, impact viral receptor binding, viral replication, and the host immune response against the viral infection. A critical factor affecting RNA viruses both ex vivo and in vivo, and defining the outcome of viral infections and the direction of viral evolution, is temperature. In this minireview, we discuss the impact of temperature on viral replication, stability, transmission, and adaptation, as well as the host innate immune response. Improving our understanding of how RNA viruses function, survive, and spread at different temperatures will improve our models of viral replication and transmission risk analyses.
KW - RNA polymerase
KW - RNA virus
KW - SARS coronavirus 2
KW - arbovirus
KW - flavivirus
KW - influenza A virus
KW - innate immune response
KW - replication
KW - respiratory virus
KW - stability
KW - temperature
KW - transmission
KW - zoonotic
UR - http://www.scopus.com/inward/record.url?scp=85140856096&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140856096&partnerID=8YFLogxK
U2 - 10.1128/mbio.02021-22
DO - 10.1128/mbio.02021-22
M3 - Review article
C2 - 35980031
AN - SCOPUS:85140856096
SN - 2161-2129
VL - 13
JO - mBio
JF - mBio
IS - 5
ER -