Decoding noncoding regulatory DNAs in metazoan genomes

M. Markstein; A. Stathopoulos; V. Markstein; P. Markstein; N. Harafuji; D. Keys; Byung In Lee; P. Richardson; D. Rokshar; M. Levine

doi:10.1109/CSB.2002.1039323

Decoding noncoding regulatory DNAs in metazoan genomes

M. Markstein
, A. Stathopoulos
, V. Markstein
, P. Markstein
, N. Harafuji
, D. Keys
, Byung In Lee
, P. Richardson
, D. Rokshar
, M. Levine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Summary form only given. The recent revelation that the human genome contains only ∼30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA-300 bp to 1,000 bp in length-that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by simple sequence inspection. One of the outstanding issues in the post-genome era is whether there is a "cis-regulatory code" that links primary DNA sequence with gene expression patterns. We have used a combination of bioinformatics methods and functional assays to determine whether coordinately regulated genes share a common "grammar".

Original language	English (US)
Title of host publication	Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5
Number of pages	1
ISBN (Electronic)	076951653X, 9780769516530
DOIs	https://doi.org/10.1109/CSB.2002.1039323
State	Published - 2002
Externally published	Yes
Event	1st International IEEE Computer Society Bioinformatics Conference, CSB 2002 - Stanford, United States Duration: Aug 14 2002 → Aug 16 2002

Publication series

Name	Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002

Other

Other	1st International IEEE Computer Society Bioinformatics Conference, CSB 2002
Country/Territory	United States
City	Stanford
Period	8/14/02 → 8/16/02

All Science Journal Classification (ASJC) codes

Artificial Intelligence
Software
Biomedical Engineering
Health Informatics

Access to Document

10.1109/CSB.2002.1039323

Cite this

Markstein, M., Stathopoulos, A., Markstein, V., Markstein, P., Harafuji, N., Keys, D., Lee, B. I., Richardson, P., Rokshar, D., & Levine, M. (2002). Decoding noncoding regulatory DNAs in metazoan genomes. In Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002 (pp. 5). Article 1039323 (Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSB.2002.1039323

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title = "Decoding noncoding regulatory DNAs in metazoan genomes",

abstract = "Summary form only given. The recent revelation that the human genome contains only ∼30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA-300 bp to 1,000 bp in length-that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by simple sequence inspection. One of the outstanding issues in the post-genome era is whether there is a {"}cis-regulatory code{"} that links primary DNA sequence with gene expression patterns. We have used a combination of bioinformatics methods and functional assays to determine whether coordinately regulated genes share a common {"}grammar{"}.",

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year = "2002",

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language = "English (US)",

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Markstein, M, Stathopoulos, A, Markstein, V, Markstein, P, Harafuji, N, Keys, D, Lee, BI, Richardson, P, Rokshar, D & Levine, M 2002, Decoding noncoding regulatory DNAs in metazoan genomes. in Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002., 1039323, Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002, Institute of Electrical and Electronics Engineers Inc., pp. 5, 1st International IEEE Computer Society Bioinformatics Conference, CSB 2002, Stanford, United States, 8/14/02. https://doi.org/10.1109/CSB.2002.1039323

Decoding noncoding regulatory DNAs in metazoan genomes. / Markstein, M.; Stathopoulos, A.; Markstein, V. et al.
Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002. Institute of Electrical and Electronics Engineers Inc., 2002. p. 5 1039323 (Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Levine, M.

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AB - Summary form only given. The recent revelation that the human genome contains only ∼30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA-300 bp to 1,000 bp in length-that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by simple sequence inspection. One of the outstanding issues in the post-genome era is whether there is a "cis-regulatory code" that links primary DNA sequence with gene expression patterns. We have used a combination of bioinformatics methods and functional assays to determine whether coordinately regulated genes share a common "grammar".

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Markstein M, Stathopoulos A, Markstein V, Markstein P, Harafuji N, Keys D et al. Decoding noncoding regulatory DNAs in metazoan genomes. In Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002. Institute of Electrical and Electronics Engineers Inc. 2002. p. 5. 1039323. (Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002). doi: 10.1109/CSB.2002.1039323

Decoding noncoding regulatory DNAs in metazoan genomes

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