Decoding noncoding regulatory DNAs in metazoan genomes

M. Markstein, A. Stathopoulos, V. Markstein, P. Markstein, N. Harafuji, D. Keys, Byung In Lee, P. Richardson, D. Rokshar, M. Levine

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Summary form only given. The recent revelation that the human genome contains only ∼30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA-300 bp to 1,000 bp in length-that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by simple sequence inspection. One of the outstanding issues in the post-genome era is whether there is a "cis-regulatory code" that links primary DNA sequence with gene expression patterns. We have used a combination of bioinformatics methods and functional assays to determine whether coordinately regulated genes share a common "grammar".

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages1
ISBN (Electronic)076951653X, 9780769516530
DOIs
StatePublished - Jan 1 2002
Externally publishedYes
Event1st International IEEE Computer Society Bioinformatics Conference, CSB 2002 - Stanford, United States
Duration: Aug 14 2002Aug 16 2002

Publication series

NameProceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002

Other

Other1st International IEEE Computer Society Bioinformatics Conference, CSB 2002
CountryUnited States
CityStanford
Period8/14/028/16/02

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Software
  • Biomedical Engineering
  • Health Informatics

Fingerprint Dive into the research topics of 'Decoding noncoding regulatory DNAs in metazoan genomes'. Together they form a unique fingerprint.

  • Cite this

    Markstein, M., Stathopoulos, A., Markstein, V., Markstein, P., Harafuji, N., Keys, D., Lee, B. I., Richardson, P., Rokshar, D., & Levine, M. (2002). Decoding noncoding regulatory DNAs in metazoan genomes. In Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002 [1039323] (Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSB.2002.1039323