@inproceedings{b2784210d9ae44108ff457d7d589e121,
title = "Decoding noncoding regulatory DNAs in metazoan genomes",
abstract = "Summary form only given. The recent revelation that the human genome contains only ∼30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA-300 bp to 1,000 bp in length-that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by simple sequence inspection. One of the outstanding issues in the post-genome era is whether there is a {"}cis-regulatory code{"} that links primary DNA sequence with gene expression patterns. We have used a combination of bioinformatics methods and functional assays to determine whether coordinately regulated genes share a common {"}grammar{"}.",
author = "M. Markstein and A. Stathopoulos and V. Markstein and P. Markstein and N. Harafuji and D. Keys and Lee, {Byung In} and P. Richardson and D. Rokshar and M. Levine",
year = "2002",
month = jan,
day = "1",
doi = "10.1109/CSB.2002.1039323",
language = "English (US)",
series = "Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002",
address = "United States",
note = "1st International IEEE Computer Society Bioinformatics Conference, CSB 2002 ; Conference date: 14-08-2002 Through 16-08-2002",
}