Decoding noncoding regulatory DNAs in metazoan genomes

M. Markstein; A. Stathopoulos; V. Markstein; P. Markstein; N. Harafuji; D. Keys; Byung In Lee; P. Richardson; D. Rokshar; M. Levine

doi:10.1109/CSB.2002.1039323

Decoding noncoding regulatory DNAs in metazoan genomes

M. Markstein, A. Stathopoulos, V. Markstein, P. Markstein, N. Harafuji, D. Keys, Byung In Lee, P. Richardson, D. Rokshar, M. Levine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Summary form only given. The recent revelation that the human genome contains only ∼30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA-300 bp to 1,000 bp in length-that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by simple sequence inspection. One of the outstanding issues in the post-genome era is whether there is a "cis-regulatory code" that links primary DNA sequence with gene expression patterns. We have used a combination of bioinformatics methods and functional assays to determine whether coordinately regulated genes share a common "grammar".

Original language	English (US)
Title of host publication	Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5
Number of pages	1
ISBN (Electronic)	076951653X, 9780769516530
DOIs	https://doi.org/10.1109/CSB.2002.1039323
State	Published - 2002
Externally published	Yes
Event	1st International IEEE Computer Society Bioinformatics Conference, CSB 2002 - Stanford, United States Duration: Aug 14 2002 → Aug 16 2002

Publication series

Name	Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002

Other

Other	1st International IEEE Computer Society Bioinformatics Conference, CSB 2002
Country/Territory	United States
City	Stanford
Period	8/14/02 → 8/16/02

All Science Journal Classification (ASJC) codes

Artificial Intelligence
Software
Biomedical Engineering
Health Informatics

Access to Document

10.1109/CSB.2002.1039323

Cite this

Markstein, M., Stathopoulos, A., Markstein, V., Markstein, P., Harafuji, N., Keys, D., Lee, B. I., Richardson, P., Rokshar, D., & Levine, M. (2002). Decoding noncoding regulatory DNAs in metazoan genomes. In Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002 (pp. 5). Article 1039323 (Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSB.2002.1039323

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Markstein, M, Stathopoulos, A, Markstein, V, Markstein, P, Harafuji, N, Keys, D, Lee, BI, Richardson, P, Rokshar, D & Levine, M 2002, Decoding noncoding regulatory DNAs in metazoan genomes. in Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002., 1039323, Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002, Institute of Electrical and Electronics Engineers Inc., pp. 5, 1st International IEEE Computer Society Bioinformatics Conference, CSB 2002, Stanford, United States, 8/14/02. https://doi.org/10.1109/CSB.2002.1039323

Decoding noncoding regulatory DNAs in metazoan genomes. / Markstein, M.; Stathopoulos, A.; Markstein, V. et al.
Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002. Institute of Electrical and Electronics Engineers Inc., 2002. p. 5 1039323 (Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Markstein M, Stathopoulos A, Markstein V, Markstein P, Harafuji N, Keys D et al. Decoding noncoding regulatory DNAs in metazoan genomes. In Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002. Institute of Electrical and Electronics Engineers Inc. 2002. p. 5. 1039323. (Proceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002). doi: 10.1109/CSB.2002.1039323

Decoding noncoding regulatory DNAs in metazoan genomes

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