@article{f77dbc434df3425395b3fc73547cf4a3,
title = "Decoding locomotion from population neural activity in moving C. Elegans",
abstract = "We investigated the neural representation of locomotion in the nematode C. elegans by recording population calcium activity during movement. We report that population activity more accurately decodes locomotion than any single neuron. Relevant signals are distributed across neurons with diverse tunings to locomotion. Two largely distinct subpopulations are informative for decoding velocity and curvature, and different neurons{\textquoteright} activities contribute features relevant for different aspects of a behavior or different instances of a behavioral motif. To validate our measurements, we labeled neurons AVAL and AVAR and found that their activity exhibited expected transients during backward locomotion. Finally, we compared population activity during movement and immobilization. Immobilization alters the correlation structure of neural activity and its dynamics. Some neurons positively correlated with AVA during movement become negatively correlated during immobilization and vice versa. This work provides needed experimental measurements that inform and constrain ongoing efforts to understand population dynamics underlying locomotion in C. elegans.",
author = "Hallinen, {Kelsey M.} and Ross Dempsey and Monika Scholz and Xinwei Yu and Ashley Linder and Francesco Randi and Anuj Sharma and Shaevitz, {Joshua W.} and Leifer, {Andrew M.}",
note = "Funding Information: 729 was supported in part by the National Science Foundation, through the Center for the Physics of Funding Information: Thanks to Sandeep Kumar and Kevin Chen for critical comments on the manuscript. This work was supported in part by the National Science Foundation, through the Center for the Physics of Biological Function (PHY-1734030 to JWS and AML) and an NSF CAREER Award (IOS-1845137 to AML) and by the Simons Foundation (SCGB #324285, and SCGB #543003, AML). ANL is supported by a National Institutes of Health institutional training grant NIH T32 MH065214 through the Princeton Neuroscience Institute. FR was supported by the Swartz Foundation via the Swartz Fellowship for Theoretical Neuroscience. Strains are distributed by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Funding Information: 732 National Institutes of Health institutional training grant NIH T32 MH065214 through the Princeton Funding Information: 731 and by the Simons Foundation (SCGB #324285, and SCGB #543003, AML). ANL is supported by a Funding Information: 733 Neuroscience Institute. FR was supported by the Swartz Foundation via the Swartz Fellowship for Publisher Copyright: {\textcopyright} 2021, eLife Sciences Publications Ltd. All rights reserved.",
year = "2021",
month = jul,
doi = "10.7554/eLife.66135",
language = "English (US)",
volume = "10",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}