TY - JOUR
T1 - Deciphering nitric oxide stress in bacteria with quantitative modeling
AU - Robinson, Jonathan L.
AU - Adolfsen, Kristin J.
AU - Brynildsen, Mark P.
N1 - Funding Information:
This work was supported in part by the National Science Foundation Graduate Research Fellowship under Grant No. DGE 1148900 , and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number R21AI105342 .
PY - 2014/6
Y1 - 2014/6
N2 - Many pathogens depend on nitric oxide (NO) detoxification and repair to establish an infection, and inhibitors of these systems are under investigation as next-generation antibiotics. Because of the broad reactivity of NO and its derivatives with biomolecules, a deep understanding of how pathogens sense and respond to NO, as an integrated system, has been elusive. Quantitative kinetic modeling has been proposed as a method to enhance analysis and understanding of NO stress at the systems-level. Here we review the motivation for, current state of, and future prospects of quantitative modeling of NO stress in bacteria, and suggest that such mathematical approaches would prove equally useful in the study of other broadly reactive antimicrobials, such as hydrogen peroxide (H2O2).
AB - Many pathogens depend on nitric oxide (NO) detoxification and repair to establish an infection, and inhibitors of these systems are under investigation as next-generation antibiotics. Because of the broad reactivity of NO and its derivatives with biomolecules, a deep understanding of how pathogens sense and respond to NO, as an integrated system, has been elusive. Quantitative kinetic modeling has been proposed as a method to enhance analysis and understanding of NO stress at the systems-level. Here we review the motivation for, current state of, and future prospects of quantitative modeling of NO stress in bacteria, and suggest that such mathematical approaches would prove equally useful in the study of other broadly reactive antimicrobials, such as hydrogen peroxide (H2O2).
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U2 - 10.1016/j.mib.2014.05.018
DO - 10.1016/j.mib.2014.05.018
M3 - Review article
C2 - 24983704
AN - SCOPUS:84903552294
SN - 1369-5274
VL - 19
SP - 16
EP - 24
JO - Current opinion in microbiology
JF - Current opinion in microbiology
IS - 1
ER -