Decatungstate-Catalyzed C(sp3)-H Sulfinylation: Rapid Access to Diverse Organosulfur Functionality

Patrick J. Sarver, Noah B. Bissonnette, David W.C. Macmillan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Here we report the direct conversion of strong, aliphatic C(sp3)-H bonds into the corresponding alkyl sulfinic acids via decatungstate photocatalysis. This transformation has been applied to a diverse range of C(sp3)-rich scaffolds, including natural products and approved pharmaceuticals, providing efficient access to complex sulfur-containing products. To demonstrate the broad potential of this methodology for the divergent synthesis of pharmaceutically relevant molecules, procedures for the diversification of the sulfinic acid products into a range of medicinally relevant functional groups have been developed.

Original languageEnglish (US)
Pages (from-to)9737-9743
Number of pages7
JournalJournal of the American Chemical Society
Volume143
Issue number26
DOIs
StatePublished - Jul 7 2021

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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