TY - JOUR
T1 - Decatungstate-Catalyzed C(sp3)-H Sulfinylation
T2 - Rapid Access to Diverse Organosulfur Functionality
AU - Sarver, Patrick J.
AU - Bissonnette, Noah B.
AU - Macmillan, David W.C.
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/7/7
Y1 - 2021/7/7
N2 - Here we report the direct conversion of strong, aliphatic C(sp3)-H bonds into the corresponding alkyl sulfinic acids via decatungstate photocatalysis. This transformation has been applied to a diverse range of C(sp3)-rich scaffolds, including natural products and approved pharmaceuticals, providing efficient access to complex sulfur-containing products. To demonstrate the broad potential of this methodology for the divergent synthesis of pharmaceutically relevant molecules, procedures for the diversification of the sulfinic acid products into a range of medicinally relevant functional groups have been developed.
AB - Here we report the direct conversion of strong, aliphatic C(sp3)-H bonds into the corresponding alkyl sulfinic acids via decatungstate photocatalysis. This transformation has been applied to a diverse range of C(sp3)-rich scaffolds, including natural products and approved pharmaceuticals, providing efficient access to complex sulfur-containing products. To demonstrate the broad potential of this methodology for the divergent synthesis of pharmaceutically relevant molecules, procedures for the diversification of the sulfinic acid products into a range of medicinally relevant functional groups have been developed.
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U2 - 10.1021/jacs.1c04722
DO - 10.1021/jacs.1c04722
M3 - Article
C2 - 34161084
AN - SCOPUS:85110144527
SN - 0002-7863
VL - 143
SP - 9737
EP - 9743
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 26
ER -