Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Jacob A. Kautzky, Tao Wang, Ryan W. Evans, David W.C. Macmillan

Research output: Contribution to journalArticle

63 Scopus citations


Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.

Original languageEnglish (US)
Pages (from-to)6522-6526
Number of pages5
JournalJournal of the American Chemical Society
Issue number21
StatePublished - May 30 2018

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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