TY - JOUR
T1 - Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids
AU - Kautzky, Jacob A.
AU - Wang, Tao
AU - Evans, Ryan W.
AU - Macmillan, David W.C.
N1 - Publisher Copyright:
Copyright © 2018 American Chemical Society.
PY - 2018/5/30
Y1 - 2018/5/30
N2 - Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.
AB - Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.
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U2 - 10.1021/jacs.8b02650
DO - 10.1021/jacs.8b02650
M3 - Article
C2 - 29754491
AN - SCOPUS:85047101051
VL - 140
SP - 6522
EP - 6526
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 21
ER -