Abstract
Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.
Original language | English (US) |
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Pages (from-to) | 6522-6526 |
Number of pages | 5 |
Journal | Journal of the American Chemical Society |
Volume | 140 |
Issue number | 21 |
DOIs | |
State | Published - May 30 2018 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry