Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Jacob A. Kautzky, Tao Wang, Ryan W. Evans, David W.C. Macmillan

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.

Original languageEnglish (US)
Pages (from-to)6522-6526
Number of pages5
JournalJournal of the American Chemical Society
Issue number21
StatePublished - May 30 2018

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


Dive into the research topics of 'Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids'. Together they form a unique fingerprint.

Cite this