An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.
|Original language||English (US)|
|Number of pages||20|
|Journal||Journal of Organic Chemistry|
|State||Published - Jul 5 2019|
All Science Journal Classification (ASJC) codes
- Organic Chemistry