Decarboxylative arylation of α-Amino acids via photoredox catalysis: A one-step conversion of biomass to drug pharmacophore

Zhiwei Zuo; David W.C. Macmillan

doi:10.1021/ja501621q

Decarboxylative arylation of α-Amino acids via photoredox catalysis: A one-step conversion of biomass to drug pharmacophore

Zhiwei Zuo, David W.C. Macmillan

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453 Scopus citations

Abstract

The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.

Original language	English (US)
Pages (from-to)	5257-5260
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	136
Issue number	14
DOIs	https://doi.org/10.1021/ja501621q
State	Published - Apr 9 2014

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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10.1021/ja501621q

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title = "Decarboxylative arylation of α-Amino acids via photoredox catalysis: A one-step conversion of biomass to drug pharmacophore",

abstract = "The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.",

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Decarboxylative arylation of α-Amino acids via photoredox catalysis: A one-step conversion of biomass to drug pharmacophore

Abstract

All Science Journal Classification (ASJC) codes

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