De novo proteins from combinatorial libraries

David A. Moffet, Michael H. Hecht

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations

Abstract

The technique used for analyzing De Novo proteins from combinatorial libraries were discussed. The sequences targeted to form a tetrameric α-helical bundle was solved and compared with respect to the calculated structures. The results showed that the binary code strategy for protein design produced a large collection of de Novo sequences that folded into soluble α-helical structures.

Original languageEnglish (US)
Pages (from-to)3191-3203
Number of pages13
JournalChemical Reviews
Volume101
Issue number10
DOIs
StatePublished - Oct 2001

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Fingerprint

Dive into the research topics of 'De novo proteins from combinatorial libraries'. Together they form a unique fingerprint.

Cite this