Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials

J. Rabinowitz; W. P. Petros; W. P. Peters

Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials

J. Rabinowitz, W. P. Petros, W. P. Peters

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

ADMINISTRATION of recombinant growth factors can result in acceleration of hematopoiesis and dose-related toxic effects. A better understanding of these new drugs requires studying not only the recombinant protein infused but also its effects on secondarily released cytokines that may have an impact on clinical response. Studies of cytokine kinetics are valuable tools for improving current growth factor regimens, and they offer insight into the design of future trials involving novel applications or combinations of cytokines.

Original language	English (US)
Pages (from-to)	40-47
Number of pages	8
Journal	Cancer Bulletin
Volume	46
Issue number	1
State	Published - 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cancer Research

Cite this

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title = "Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials",

abstract = "ADMINISTRATION of recombinant growth factors can result in acceleration of hematopoiesis and dose-related toxic effects. A better understanding of these new drugs requires studying not only the recombinant protein infused but also its effects on secondarily released cytokines that may have an impact on clinical response. Studies of cytokine kinetics are valuable tools for improving current growth factor regimens, and they offer insight into the design of future trials involving novel applications or combinations of cytokines.",

author = "J. Rabinowitz and Petros, {W. P.} and Peters, {W. P.}",

year = "1994",

language = "English (US)",

volume = "46",

pages = "40--47",

journal = "Cancer Bulletin",

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number = "1",

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T1 - Cytokine kinetics

T2 - Clinical pharmacology studies complementing recombinant growth factor trials

AU - Rabinowitz, J.

AU - Petros, W. P.

AU - Peters, W. P.

PY - 1994

Y1 - 1994

N2 - ADMINISTRATION of recombinant growth factors can result in acceleration of hematopoiesis and dose-related toxic effects. A better understanding of these new drugs requires studying not only the recombinant protein infused but also its effects on secondarily released cytokines that may have an impact on clinical response. Studies of cytokine kinetics are valuable tools for improving current growth factor regimens, and they offer insight into the design of future trials involving novel applications or combinations of cytokines.

AB - ADMINISTRATION of recombinant growth factors can result in acceleration of hematopoiesis and dose-related toxic effects. A better understanding of these new drugs requires studying not only the recombinant protein infused but also its effects on secondarily released cytokines that may have an impact on clinical response. Studies of cytokine kinetics are valuable tools for improving current growth factor regimens, and they offer insight into the design of future trials involving novel applications or combinations of cytokines.

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M3 - Comment/debate

AN - SCOPUS:0028211182

SN - 0740-820X

VL - 46

SP - 40

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JO - Cancer Bulletin

JF - Cancer Bulletin

IS - 1

ER -

Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials

Abstract

All Science Journal Classification (ASJC) codes

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