The common sugar dulcitol is transformed into a hex-1,5-diyne with 3,4-dihydroxyls modified as an acetonide; this serves as a building block for the cyclic ene-diynes and allows mild and efficient introduction of the key ene unit at a late stage in ene-diyne synthesis using the reactive Corey-Winter reagent.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jun 25 1993|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry