Cycle-specific organocascade catalysis: Application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis

Bryon Simmons; Abbas M. Walji; David W.C. MacMillan

doi:10.1002/anie.200900220

Cycle-specific organocascade catalysis: Application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis

Bryon Simmons, Abbas M. Walji, David W.C. MacMillan

Research output: Contribution to journal › Article › peer-review

235 Scopus citations

Abstract

United in effort: The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, - hydro-oxidation, and -amino-oxidation of olefins (see picture). An enantioselective organocascade catalysis was also applied in the synthesis of a complex natural product.

Original language	English (US)
Pages (from-to)	4349-4353
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	24
DOIs	https://doi.org/10.1002/anie.200900220
State	Published - Jun 2 2009

All Science Journal Classification (ASJC) codes

Chemistry(all)
Catalysis

Keywords

Cascade reactions
Enantioselectivity
Natural products
Organocatalysis

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10.1002/anie.200900220

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KW - Enantioselectivity

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Cycle-specific organocascade catalysis: Application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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