Cycle-specific organocascade catalysis: Application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis

Bryon Simmons, Abbas M. Walji, David W.C. MacMillan

Research output: Contribution to journalArticle

213 Scopus citations

Abstract

United in effort: The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, - hydro-oxidation, and -amino-oxidation of olefins (see picture). An enantioselective organocascade catalysis was also applied in the synthesis of a complex natural product.

Original languageEnglish (US)
Pages (from-to)4349-4353
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number24
DOIs
StatePublished - Jun 2 2009

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • Cascade reactions
  • Enantioselectivity
  • Natural products
  • Organocatalysis

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