C(sp2)-H Activation with Pyridine Dicarbene Iron Dialkyl Complexes: Hydrogen Isotope Exchange of Arenes Using Benzene- d6as a Deuterium Source

Javier Corpas, Peter Viereck, Paul J. Chirik

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Treatment of pyridine dicarbene iron dialkyl complexes with low (≪1 atm) pressures of H2 in a benzene-d6 solution promoted rapid hydrogen isotope exchange (HIE) of the C(sp2)-H bonds in both electron-poor and -rich aromatic and heteroaromatic rings with benzene-d6 as the deuterium source. The iron-catalyzed reaction proceeded with predictable regioselectivity, engaging sterically accessible C-H bonds including ortho-to-fluorine sites. The site selectivity for the catalytic HIE reaction was studied to identify the kinetic preferences for C-H activation. Structure-activity relationship studies with a series of iron precatalysts established that introduction of substituents at the 3- and 5-positions of pyridine of the pincer significantly accelerated HIE. Mechanistic studies identified N2 as an inhibitor of C-H activation, while H2 served to generate the active catalyst.

Original languageEnglish (US)
Pages (from-to)8640-8647
Number of pages8
JournalACS Catalysis
Volume10
Issue number15
DOIs
StatePublished - Aug 7 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • C(sp)-H functionalization
  • C-H activation
  • hydrogen isotope exchange
  • iron catalysis
  • regioselectivity

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