Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

Philip J. Pye; Kai Rossen; Steven A. Weissman; Ashok Maliakal; Robert A. Reamer; Richard Ball; Nancy N. Tsou; R. P. Volante; Paul J. Reider

doi:10.1002/1521-3765(20020315)8:6<1372::AID-CHEM1372>3.0.CO;2-6

Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

Philip J. Pye, Kai Rossen, Steven A. Weissman, Ashok Maliakal, Robert A. Reamer, Richard Ball, Nancy N. Tsou, R. P. Volante, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

Original language	English (US)
Pages (from-to)	1372-1376
Number of pages	5
Journal	Chemistry - A European Journal
Volume	8
Issue number	6
DOIs	https://doi.org/10.1002/1521-3765(20020315)8:6<1372::AID-CHEM1372>3.0.CO;2-6
State	Published - Mar 15 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Organic Chemistry

Keywords

Asymmetric synthesis
Crystallization-driven transformation
Dihydroxylation
Mitsunobu reaction
Substance P inhibitors

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10.1002/1521-3765(20020315)8:6<1372::AID-CHEM1372>3.0.CO;2-6

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title = "Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors",

abstract = "A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.",

keywords = "Asymmetric synthesis, Crystallization-driven transformation, Dihydroxylation, Mitsunobu reaction, Substance P inhibitors",

author = "Pye, {Philip J.} and Kai Rossen and Weissman, {Steven A.} and Ashok Maliakal and Reamer, {Robert A.} and Richard Ball and Tsou, {Nancy N.} and Volante, {R. P.} and Reider, {Paul J.}",

year = "2002",

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doi = "10.1002/1521-3765(20020315)8:6<1372::AID-CHEM1372>3.0.CO;2-6",

language = "English (US)",

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T1 - Crystallization-induced diastereoselection

T2 - Asymmetric synthesis of substance P inhibitors

AU - Pye, Philip J.

AU - Rossen, Kai

AU - Weissman, Steven A.

AU - Maliakal, Ashok

AU - Reamer, Robert A.

AU - Ball, Richard

AU - Tsou, Nancy N.

AU - Volante, R. P.

AU - Reider, Paul J.

PY - 2002/3/15

Y1 - 2002/3/15

N2 - A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

AB - A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

KW - Asymmetric synthesis

KW - Crystallization-driven transformation

KW - Dihydroxylation

KW - Mitsunobu reaction

KW - Substance P inhibitors

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U2 - 10.1002/1521-3765(20020315)8:6<1372::AID-CHEM1372>3.0.CO;2-6

DO - 10.1002/1521-3765(20020315)8:6<1372::AID-CHEM1372>3.0.CO;2-6

M3 - Article

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SN - 0947-6539

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 6

ER -

Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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