Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

Philip J. Pye, Kai Rossen, Steven A. Weissman, Ashok Maliakal, Robert A. Reamer, Richard Ball, Nancy N. Tsou, R. P. Volante, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

Original languageEnglish (US)
Pages (from-to)1372-1376
Number of pages5
JournalChemistry - A European Journal
Issue number6
StatePublished - Mar 15 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry


  • Asymmetric synthesis
  • Crystallization-driven transformation
  • Dihydroxylation
  • Mitsunobu reaction
  • Substance P inhibitors


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