Abstract
An efficient, catalytic method for the total conversion of a racemate into a single enantiomer is reported. The combined, in situ resolution-racemization was applied to 3(RS)-amino-l,3-dihydro-l-methyl-5-phenyl-2tf-l,4-benzodiazepin-2-one to produce the optically pure S enantiomer in 91% yield. Acylation with indole-2-carboxylic acid produced L-364,718, an extremely potent nonpeptidal peripheral CCK antagonist.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 955-957 |
| Number of pages | 3 |
| Journal | Journal of Organic Chemistry |
| Volume | 52 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 1 1987 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
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