Cross-regulatory interactions among pair-rule genes in Drosophila

Katherine Harding, Christine Rushlow, Helen J. Doyle, Timothy Hoey, Michael Levine

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The pair-rule genes of Drosophila are required for the subdivision of the developing embryo into a repeating series of homologous body segments. One of the pair-rule genes, even-skipped (eve), appears to be particularly important for the overall segmentation pattern since eve- embryos lack all segmental subdivisions in the middle body region. On the basis of homeo box cross-homology we have isolated a gene, S72, which probably corresponds to eve. In embryo tissue sections S72 transcripts show a periodic distribution pattern. The eve- phenotype appears to involve altered patterns of fushi tarazu and engrailed expression. These and other findings suggest that pair-rule gene expression might involve hierarchical cross-regulatory interactions.

Original languageEnglish (US)
Pages (from-to)961-963
Number of pages3
Issue number4767
StatePublished - 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'Cross-regulatory interactions among pair-rule genes in Drosophila'. Together they form a unique fingerprint.

Cite this