Cross-regulatory interactions among pair-rule genes in Drosophila

K. Harding, C. Rushlow, H. J. Doyle, T. Hoey, M. Levine

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The pair-rule genes of Drosophila are required for the subdivision of the developing embryo into a repeating series of homologous body segments. One of the pair-rule genes, even-skipped (eve), appears to be particularly important for the overall segmentation pattern since eve- embryos lack all segmental subdivisions in the middle body region. On the basis of homeo box cross-homology we have isolated a gene, S72, which probably corresponds to eve. In embryo tissue sections S72 transcripts show a periodic distribution pattern. The eve- phenotype appears to involve altered patterns of fushi tarazu and engrailed expression. These and other findings suggest that pair-rule gene expression might involve hierarchical cross-regulatory interactions.

Original languageEnglish (US)
Pages (from-to)953-959
Number of pages7
JournalScience
Volume233
Issue number4767
DOIs
StatePublished - Nov 12 1986

All Science Journal Classification (ASJC) codes

  • General

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