Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8+ T cells

Alexander Ploss; An Tran; Ewa Menet; Ingrid Leiner; Eric G. Pamer

doi:10.1128/IAI.73.7.4423-4426.2005

Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8⁺ T cells

Alexander Ploss, An Tran, Ewa Menet, Ingrid Leiner, Eric G. Pamer

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

H2-M3-restricted CD8⁺ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

Original language	English (US)
Pages (from-to)	4423-4426
Number of pages	4
Journal	Infection and Immunity
Volume	73
Issue number	7
DOIs	https://doi.org/10.1128/IAI.73.7.4423-4426.2005
State	Published - Jul 2005

All Science Journal Classification (ASJC) codes

Infectious Diseases
Parasitology
Microbiology
Immunology

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10.1128/IAI.73.7.4423-4426.2005

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AU - Ploss, Alexander

AU - Tran, An

AU - Menet, Ewa

AU - Leiner, Ingrid

AU - Pamer, Eric G.

PY - 2005/7

Y1 - 2005/7

N2 - H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

AB - H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

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SN - 0019-9567

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Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8⁺ T cells

Abstract

All Science Journal Classification (ASJC) codes

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