Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8+ T cells

Alexander Ploss, An Tran, Ewa Menet, Ingrid Leiner, Eric G. Pamer

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

Original languageEnglish (US)
Pages (from-to)4423-4426
Number of pages4
JournalInfection and Immunity
Volume73
Issue number7
DOIs
StatePublished - Jul 2005

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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