Critical particle size for fractionation by deterministic lateral displacement

David W. Inglis, John A. Davis, Robert H. Austin, James C. Sturm

Research output: Contribution to journalArticlepeer-review

267 Scopus citations

Abstract

The fractionation of small particles in a liquid based on their size in a micropost array by deterministic lateral displacement was recently demonstrated with unprecedented resolution (L. R. Huang, E. C. Cox, R. H. Austin and J. C. Sturm, Science, 2004, 304, 987-990, ref. 1). In this paper, we present a model of how the critical particle size for fractionation depends on the micropost geometry, depending specifically on the gap between posts, the offset of posts in one row with respect to another, and whether the fluid is driven by hydrodynamics or by electroosmosis. In general the critical particle diameter is much smaller than the gap, which prevents clogging. The model is supported by data with particles from 2.3 to 22 μm.

Original languageEnglish (US)
Pages (from-to)655-658
Number of pages4
JournalLab on a Chip
Volume6
Issue number5
DOIs
StatePublished - 2006

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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