@article{ca97ec861a2e489083181a9aac4d0876,
title = "CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling",
abstract = "Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.",
keywords = "C. elegans, CREB, Hedgehog, TGF-beta, WRT-10, lifespan, oocyte quality, reproduction, reproductive span",
author = "Templeman, {Nicole M.} and Vanessa Cota and William Keyes and Rachel Kaletsky and Murphy, {Coleen T.}",
note = "Funding Information: We thank Shijing Luo, Jasmine Ashraf, and Daniel Xu for their contributions toward experiments; Christina DeCoste and Katherine Rittenbach in the Princeton Molecular Biology Flow Cytometry Resource Facility (partially supported by the Cancer Institute of New Jersey Cancer Center support grant; P30CA072720 ); the Princeton Genomics Core Facility; Patricia Kuwabara for providing the ptc-1 RNAi clone; the Caenorhabditis Genetics Center (CGC) for strains; and Murphy Lab members for comments on the manuscript. N.M.T. was supported by a Canadian Institutes of Health Research Banting Postdoctoral Fellowship. The study was supported by the HHMI faculty scholar program ( AWD1005048 ), the Glenn Foundation for Medical Research (GMFR CNV1001899 ), and NIH New Innovator ( 1DP2OD004402-01 ), DP1 Pioneer ( NIGMS 1DP2OD004402-01 ), and March of Dimes awards to C.T.M. ",
year = "2020",
month = jul,
day = "6",
doi = "10.1016/j.devcel.2020.05.023",
language = "English (US)",
volume = "54",
pages = "92--105.e5",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "1",
}