CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman; Vanessa Cota; William Keyes; Rachel Kaletsky; Coleen T. Murphy

doi:10.1016/j.devcel.2020.05.023

CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman, Vanessa Cota, William Keyes, Rachel Kaletsky, Coleen T. Murphy

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

Original language	English (US)
Pages (from-to)	92-105.e5
Journal	Developmental cell
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2020.05.023
State	Published - Jul 6 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

Keywords

C. elegans
CREB
Hedgehog
TGF-beta
WRT-10
lifespan
oocyte quality
reproduction
reproductive span

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Templeman, N. M., Cota, V., Keyes, W., Kaletsky, R., & Murphy, C. T. (2020). CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling. Developmental cell, 54(1), 92-105.e5. https://doi.org/10.1016/j.devcel.2020.05.023

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