CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman, Vanessa Cota, William Keyes, Rachel Kaletsky, Coleen T. Murphy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

Original languageEnglish (US)
Pages (from-to)92-105.e5
JournalDevelopmental cell
Volume54
Issue number1
DOIs
StatePublished - Jul 6 2020

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Keywords

  • C. elegans
  • CREB
  • Hedgehog
  • TGF-beta
  • WRT-10
  • lifespan
  • oocyte quality
  • reproduction
  • reproductive span

Fingerprint Dive into the research topics of 'CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling'. Together they form a unique fingerprint.

  • Cite this