CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman, Vanessa Cota, William Keyes, Rachel Kaletsky, Coleen T. Murphy

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

Original languageEnglish (US)
Pages (from-to)92-105.e5
JournalDevelopmental cell
Issue number1
StatePublished - Jul 6 2020

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Cell Biology
  • Developmental Biology


  • C. elegans
  • CREB
  • Hedgehog
  • TGF-beta
  • WRT-10
  • lifespan
  • oocyte quality
  • reproduction
  • reproductive span


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