CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman; Vanessa Cota; William Keyes; Rachel Kaletsky; Coleen T. Murphy

doi:10.1016/j.devcel.2020.05.023

CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman, Vanessa Cota, William Keyes, Rachel Kaletsky, Coleen T. Murphy

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

Original language	English (US)
Pages (from-to)	92-105.e5
Journal	Developmental cell
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2020.05.023
State	Published - Jul 6 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

Keywords

C. elegans
CREB
Hedgehog
TGF-beta
WRT-10
lifespan
oocyte quality
reproduction
reproductive span

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10.1016/j.devcel.2020.05.023

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title = "CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling",

abstract = "Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.",

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AU - Templeman, Nicole M.

AU - Cota, Vanessa

AU - Keyes, William

AU - Kaletsky, Rachel

AU - Murphy, Coleen T.

PY - 2020/7/6

Y1 - 2020/7/6

N2 - Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

AB - Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

KW - C. elegans

KW - CREB

KW - Hedgehog

KW - TGF-beta

KW - WRT-10

KW - lifespan

KW - oocyte quality

KW - reproduction

KW - reproductive span

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CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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