CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman; Vanessa Cota; William Keyes; Rachel Kaletsky; Coleen T. Murphy

doi:10.1016/j.devcel.2020.05.023

CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Nicole M. Templeman, Vanessa Cota, William Keyes, Rachel Kaletsky, Coleen T. Murphy

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

Original language	English (US)
Pages (from-to)	92-105.e5
Journal	Developmental cell
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2020.05.023
State	Published - Jul 6 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

Keywords

C. elegans
CREB
Hedgehog
TGF-beta
WRT-10
lifespan
oocyte quality
reproduction
reproductive span

Access to Document

10.1016/j.devcel.2020.05.023

Cite this

@article{ca97ec861a2e489083181a9aac4d0876,

title = "CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling",

abstract = "Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.",

keywords = "C. elegans, CREB, Hedgehog, TGF-beta, WRT-10, lifespan, oocyte quality, reproduction, reproductive span",

author = "Templeman, {Nicole M.} and Vanessa Cota and William Keyes and Rachel Kaletsky and Murphy, {Coleen T.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jul,

day = "6",

doi = "10.1016/j.devcel.2020.05.023",

language = "English (US)",

volume = "54",

pages = "92--105.e5",

journal = "Developmental cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

AU - Templeman, Nicole M.

AU - Cota, Vanessa

AU - Keyes, William

AU - Kaletsky, Rachel

AU - Murphy, Coleen T.

PY - 2020/7/6

Y1 - 2020/7/6

N2 - Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

AB - Templeman et al. describe how the transcription factor CREB regulates reproductive aging. In the hypodermis, a Caenorhabditis elegans metabolic tissue, CREB acts downstream of TGF-β Sma/Mab signaling to control oocyte quality maintenance and the rate of reproductive decline. CREB exerts these effects via Hedgehog-related WRT-10 and germline Patched-related receptors.

KW - C. elegans

KW - CREB

KW - Hedgehog

KW - TGF-beta

KW - WRT-10

KW - lifespan

KW - oocyte quality

KW - reproduction

KW - reproductive span

UR - http://www.scopus.com/inward/record.url?scp=85086909828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85086909828&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2020.05.023

DO - 10.1016/j.devcel.2020.05.023

M3 - Article

C2 - 32544391

AN - SCOPUS:85086909828

SN - 1534-5807

VL - 54

SP - 92-105.e5

JO - Developmental cell

JF - Developmental cell

IS - 1

ER -

CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this