Cradle of Evil: Osteogenic Niche for Early Bone Metastasis

Hanqiu Zheng, Yibin Kang

Research output: Contribution to journalShort survey

5 Scopus citations

Abstract

Bone metastasis often emerges long after the initial dissemination of cancer cells. In this issue of Cancer Cell, Wang and colleagues demonstrate that disseminated breast cancer cells engage osteogenic niches in the bone through heterotypic adherins junctions. This interaction activates mTOR signaling in cancer cells and supports their expansion to micrometastases. Bone metastasis often emerges long after the initial dissemination of cancer cells. In this issue of Cancer Cell, Wang and colleagues demonstrate that disseminated breast cancer cells engage osteogenic niches in the bone through heterotypic adherins junctions. This interaction activates mTOR signaling in cancer cells and supports their expansion to micrometastases.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalCancer Cell
Volume27
Issue number2
DOIs
StatePublished - Feb 9 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

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