We present and review coupled two-way clustering, a method designed to mine gene expression data. The method identifies submatrices of the total expression matrix, whose clustering analysis reveals partitions of samples (and genes) into biologically relevant classes. We demonstrate, on data from colon and breast cancer, that we are able to identify partitions that elude standard clustering analysis.
All Science Journal Classification (ASJC) codes
- Computational Mathematics
- Molecular Biology
- Statistics and Probability
- Computer Science Applications
- Computational Theory and Mathematics