Abstract
Recently, the hypothesis that protein motions are involved in enzymatic turnover has gained significant attention. We review cases where there is evidence that protein motions are rate-limiting in the overall catalytic cycle and examine experimental and theoretical evidence for how such motions enhance the probability of sampling the transition state configurations relative to the ground state. The impact of tunneling, the possible role of vibrational coupling and the value of conformational chemical landscapes are also scrutinized.
Original language | English (US) |
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Pages (from-to) | 644-651 |
Number of pages | 8 |
Journal | Current Opinion in Chemical Biology |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2010 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry