TY - JOUR
T1 - cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila
AU - Roth, Siegfried
AU - Shira Neuman-Silberberg, F.
AU - Barcelo, Gail
AU - Schüpbach, Trudi
PY - 1995/6/16
Y1 - 1995/6/16
N2 - In Drosophila, the dorsal-ventral polarity of the egg chamber depends on the localization of the oocyte nucleus and the gurken RNA to the dorsal-anterior corner of the oocyte. Gurken protein presumably acts as a ligand for the Drosophila EGF receptor (torpedo/DER) expressed in the somatic follicle cells surrounding the oocyte. cornichon is a gene required in the germline for dorsal-ventral signaling. cornichon, gurken, and torpedo also function in an earlier signaling event that establishes posterior follicle cell fates and specifies the anterior-posterior polarity of the egg chamber. Mutations in all three genes prevent the formation of a correctly polarized microtubule cytoskeleton required for proper localization of the anterior and posterior determinants bicoid and oskar and for the asymmetric positioning of the oocyte nucleus.
AB - In Drosophila, the dorsal-ventral polarity of the egg chamber depends on the localization of the oocyte nucleus and the gurken RNA to the dorsal-anterior corner of the oocyte. Gurken protein presumably acts as a ligand for the Drosophila EGF receptor (torpedo/DER) expressed in the somatic follicle cells surrounding the oocyte. cornichon is a gene required in the germline for dorsal-ventral signaling. cornichon, gurken, and torpedo also function in an earlier signaling event that establishes posterior follicle cell fates and specifies the anterior-posterior polarity of the egg chamber. Mutations in all three genes prevent the formation of a correctly polarized microtubule cytoskeleton required for proper localization of the anterior and posterior determinants bicoid and oskar and for the asymmetric positioning of the oocyte nucleus.
UR - http://www.scopus.com/inward/record.url?scp=0029058415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029058415&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(95)90016-0
DO - 10.1016/0092-8674(95)90016-0
M3 - Article
C2 - 7540118
AN - SCOPUS:0029058415
SN - 0092-8674
VL - 81
SP - 967
EP - 978
JO - Cell
JF - Cell
IS - 6
ER -