Coordinating Cell Cycle Remodeling with Transcriptional Activation at the Drosophila MBT

Shelby A. Blythe, Eric F. Wieschaus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

42 Scopus citations


During the maternal-to-zygotic transition (MZT), major changes in cell cycle regulation coincide with large-scale zygotic genome activation. In this chapter, we discuss the current understanding of how the cell cycle is remodeled over the course of the Drosophila MZT, and how the temporal precision of this event is linked to contemporaneous alterations in genome-wide chromatin structure and transcriptional activity. The cell cycle is initially lengthened during the MZT by activation of the DNA replication checkpoint but, subsequently, zygotically supplied factors are essential for establishing lasting modifications to the cell cycle.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
Subtitle of host publicationThe Maternal-to-Zygotic Transition, 2015
EditorsHoward D. Lipshitz
PublisherAcademic Press Inc.
Number of pages36
ISBN (Print)9780124095236
StatePublished - 2015

Publication series

NameCurrent Topics in Developmental Biology
ISSN (Print)0070-2153

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Developmental Biology


  • Cell cycle
  • Chromatin
  • DNA Damage Response
  • Drosophila
  • Midblastula transition
  • Transcription


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