Coordinate regulation of an extended chromosome domain

Vincent C. Calhoun, Michael Levine

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Spitz et al. (2003)([this issue of Cell]) describe the properties of a novel cis-regulatory DNA element, the global control region (GCR), which regulates gene expression over distances of several hundred kilobases at the mouse HoxD complex. The GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes within developing limbs.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
Issue number3
StatePublished - May 2 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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