Convolutional networks on graphs for learning molecular fingerprints

David Duvenaud, Dougal Maclaurin, Jorge Aguilera-Iparraguirre, Rafael Gómez-Bombarelli, Timothy Hirzel, Alán Aspuru-Guzik, Ryan P. Adams

Research output: Contribution to journalConference articlepeer-review

1687 Scopus citations

Abstract

We introduce a convolutional neural network that operates directly on graphs. These networks allow end-to-end learning of prediction pipelines whose inputs are graphs of arbitrary size and shape. The architecture we present generalizes standard molecular feature extraction methods based on circular fingerprints. We show that these data-driven features are more interpretable, and have better predictive performance on a variety of tasks.

Original languageEnglish (US)
Pages (from-to)2224-2232
Number of pages9
JournalAdvances in Neural Information Processing Systems
Volume2015-January
StatePublished - 2015
Externally publishedYes
Event29th Annual Conference on Neural Information Processing Systems, NIPS 2015 - Montreal, Canada
Duration: Dec 7 2015Dec 12 2015

All Science Journal Classification (ASJC) codes

  • Computer Networks and Communications
  • Information Systems
  • Signal Processing

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