Convergent deployment of ancestral functions during the evolution of mammalian flight membranes

Charles Y. Feigin, Jorge A. Moreno, Raul Ramos, Sarah A. Mereby, Ares Alivisatos, Wei Wang, Renée Van Amerongen, Jasmin Camacho, John J. Rasweiler, Richard R. Behringer, Bruce Ostrow, Maksim V. Plikus, Ricardo Mallarino

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Lateral flight membranes, or patagia, have evolved repeatedly in diverse mammalian lineages. While little is known about patagium development, its recurrent evolution may suggest a shared molecular basis. By combining transcriptomics, developmental experiments, and mouse transgenics, we demonstrate that lateral Wnt5a expression in the marsupial sugar glider (Petaurus breviceps) promotes the differentiation of its patagium primordium. We further show that this function of Wnt5a reprises ancestral roles in skin morphogenesis predating mammalian flight and has been convergently used during patagium evolution in eutherian bats. Moreover, we find that many genes involved in limb development have been redeployed during patagium outgrowth in both the sugar glider and bat. Together, our findings reveal that deeply conserved genetic toolkits contribute to the evolutionary transition to flight in mammals.

Original languageEnglish (US)
Article numbereade7511
JournalScience Advances
Volume9
Issue number12
DOIs
StatePublished - Mar 2023

All Science Journal Classification (ASJC) codes

  • General

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