TY - JOUR
T1 - Control of the initiation of homeotic gene expression by the gap genes giant and tailless in Drosophila
AU - Reinitz, John
AU - Levine, Michael
N1 - Funding Information:
We thank Kate Harding for probes, for unpublished data, for expert technical advice, and most of all for incisive comments and observations throughout the course of this work. We thank T. Strecker for sharing unpublished data and valuable discussions. We thank R. Moss for Fig. lb, P. Macdonald and H. Jackie for hb DNA, S. Sakunju for the c&d-A probe, and J. Lengyel and J. Mohler for fly stocks. This work was supported by grants from the NIH to M.L. J.R. was supported by fellowship DRG-914 from the Damon Runyon/Walter Win-chell Cancer Research Foundation.
PY - 1990/7
Y1 - 1990/7
N2 - The process of segmentation in Drosophila is controlled by both maternal and zygotic genes. Members of the gap class of segmentation genes play a key role in this process by interpreting maternal information and controlling the expression of pair-rule and homeotic genes. We have analyzed the pattern of expression of a variety of homeotic, pair-rule, and gap genes in tailless and giant gap mutants. tailless acts in two domains, one anterodorsal and one posterior. In its anterior domain tailless exerts a repressive effect on the expression of fushi tarazu, hunchback, and Deformed. In its posterior domain of action, tailless is responsible for the establishment of Abdominal-B expression and demarcating the posterior boundary of the initial domain of expression of Ultrabithorax. giant is an early zygotic regulator of the gap gene hunchback: in giant- embryos, alterations in the anterior domain of hunchback expression are visible by the beginning of cycle 14. giant also regulates the establishment of the expression patterns of Antennapedia and Abdominal-B. In particular, giant is the factor that controls the anterior limit of early Antennapedia expression.
AB - The process of segmentation in Drosophila is controlled by both maternal and zygotic genes. Members of the gap class of segmentation genes play a key role in this process by interpreting maternal information and controlling the expression of pair-rule and homeotic genes. We have analyzed the pattern of expression of a variety of homeotic, pair-rule, and gap genes in tailless and giant gap mutants. tailless acts in two domains, one anterodorsal and one posterior. In its anterior domain tailless exerts a repressive effect on the expression of fushi tarazu, hunchback, and Deformed. In its posterior domain of action, tailless is responsible for the establishment of Abdominal-B expression and demarcating the posterior boundary of the initial domain of expression of Ultrabithorax. giant is an early zygotic regulator of the gap gene hunchback: in giant- embryos, alterations in the anterior domain of hunchback expression are visible by the beginning of cycle 14. giant also regulates the establishment of the expression patterns of Antennapedia and Abdominal-B. In particular, giant is the factor that controls the anterior limit of early Antennapedia expression.
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U2 - 10.1016/0012-1606(90)90053-L
DO - 10.1016/0012-1606(90)90053-L
M3 - Article
C2 - 1972684
AN - SCOPUS:0025297418
SN - 0012-1606
VL - 140
SP - 57
EP - 72
JO - Developmental biology
JF - Developmental biology
IS - 1
ER -