Control of Neuronal Survival and Development Using Conductive Diamond

Samira Falahatdoost; Yair D.J. Prawer; Danli Peng; Andre Chambers; Hualin Zhan; Leon Pope; Alastair Stacey; Arman Ahnood; Hassan N. Al Hashem; Sorel E. De León; David J. Garrett; Kate Fox; Michael B. Clark; Michael R. Ibbotson; Steven Prawer; Wei Tong

doi:10.1021/acsami.3c14680

Control of Neuronal Survival and Development Using Conductive Diamond

Samira Falahatdoost, Yair D.J. Prawer, Danli Peng, Andre Chambers, Hualin Zhan, Leon Pope, Alastair Stacey, Arman Ahnood, Hassan N. Al Hashem, Sorel E. De León, David J. Garrett, Kate Fox, Michael B. Clark, Michael R. Ibbotson, Steven Prawer, Wei Tong

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.

Original language	English (US)
Pages (from-to)	4361-4374
Number of pages	14
Journal	ACS Applied Materials and Interfaces
Volume	16
Issue number	4
DOIs	https://doi.org/10.1021/acsami.3c14680
State	Published - Jan 31 2024
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science

Keywords

Conductive diamond
N-UNCD
Near-infrared illumination
Neural engineering
Neurite outgrowth

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10.1021/acsami.3c14680

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Falahatdoost, S., Prawer, Y. D. J., Peng, D., Chambers, A., Zhan, H., Pope, L., Stacey, A., Ahnood, A., Al Hashem, H. N., De León, S. E., Garrett, D. J., Fox, K., Clark, M. B., Ibbotson, M. R., Prawer, S., & Tong, W. (2024). Control of Neuronal Survival and Development Using Conductive Diamond. ACS Applied Materials and Interfaces, 16(4), 4361-4374. https://doi.org/10.1021/acsami.3c14680

@article{bf2e2b2450e342f9b128e1db873ee334,

title = "Control of Neuronal Survival and Development Using Conductive Diamond",

abstract = "This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.",

keywords = "Conductive diamond, N-UNCD, Near-infrared illumination, Neural engineering, Neurite outgrowth",

author = "Samira Falahatdoost and Prawer, \{Yair D.J.\} and Danli Peng and Andre Chambers and Hualin Zhan and Leon Pope and Alastair Stacey and Arman Ahnood and \{Al Hashem\}, \{Hassan N.\} and \{De Le{\'o}n\}, \{Sorel E.\} and Garrett, \{David J.\} and Kate Fox and Clark, \{Michael B.\} and Ibbotson, \{Michael R.\} and Steven Prawer and Wei Tong",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Published by American Chemical Society.",

year = "2024",

month = jan,

day = "31",

doi = "10.1021/acsami.3c14680",

language = "English (US)",

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journal = "ACS Applied Materials and Interfaces",

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Falahatdoost, S, Prawer, YDJ, Peng, D, Chambers, A, Zhan, H, Pope, L, Stacey, A, Ahnood, A, Al Hashem, HN, De León, SE, Garrett, DJ, Fox, K, Clark, MB, Ibbotson, MR, Prawer, S & Tong, W 2024, 'Control of Neuronal Survival and Development Using Conductive Diamond', ACS Applied Materials and Interfaces, vol. 16, no. 4, pp. 4361-4374. https://doi.org/10.1021/acsami.3c14680

TY - JOUR

T1 - Control of Neuronal Survival and Development Using Conductive Diamond

AU - Falahatdoost, Samira

AU - Prawer, Yair D.J.

AU - Peng, Danli

AU - Chambers, Andre

AU - Zhan, Hualin

AU - Pope, Leon

AU - Stacey, Alastair

AU - Ahnood, Arman

AU - Al Hashem, Hassan N.

AU - De León, Sorel E.

AU - Garrett, David J.

AU - Fox, Kate

AU - Clark, Michael B.

AU - Ibbotson, Michael R.

AU - Prawer, Steven

AU - Tong, Wei

PY - 2024/1/31

Y1 - 2024/1/31

N2 - This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.

AB - This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.

KW - Conductive diamond

KW - N-UNCD

KW - Near-infrared illumination

KW - Neural engineering

KW - Neurite outgrowth

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M3 - Article

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AN - SCOPUS:85183498088

SN - 1944-8244

VL - 16

SP - 4361

EP - 4374

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 4

ER -

Control of Neuronal Survival and Development Using Conductive Diamond

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All Science Journal Classification (ASJC) codes

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