Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors

Christopher M. Meighan; Jean E. Schwarzbauer

doi:10.1101/gad.1534807

Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors

Christopher M. Meighan, Jean E. Schwarzbauer

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the α integrin genes, ina-1 and pat-2. Utilizing vab-3 mutants, we show that the down-regulation of ina-1 is necessary for DTC migration cessation and the up-regulation of pat-2 is required for directionality. These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size.

Original language	English (US)
Pages (from-to)	1615-1620
Number of pages	6
Journal	Genes and Development
Volume	21
Issue number	13
DOIs	https://doi.org/10.1101/gad.1534807
State	Published - Jul 1 2007

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

Keywords

Cell migration
Integrins
Organogenesis
Pax6

Access to Document

10.1101/gad.1534807

Cite this

@article{f9bcc5eeaa4445aa90fc92d1de4d06dd,

title = "Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors",

abstract = "Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the α integrin genes, ina-1 and pat-2. Utilizing vab-3 mutants, we show that the down-regulation of ina-1 is necessary for DTC migration cessation and the up-regulation of pat-2 is required for directionality. These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size.",

keywords = "Cell migration, Integrins, Organogenesis, Pax6",

author = "Meighan, {Christopher M.} and Schwarzbauer, {Jean E.}",

year = "2007",

month = jul,

day = "1",

doi = "10.1101/gad.1534807",

language = "English (US)",

volume = "21",

pages = "1615--1620",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "13",

}

TY - JOUR

T1 - Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors

AU - Meighan, Christopher M.

AU - Schwarzbauer, Jean E.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the α integrin genes, ina-1 and pat-2. Utilizing vab-3 mutants, we show that the down-regulation of ina-1 is necessary for DTC migration cessation and the up-regulation of pat-2 is required for directionality. These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size.

AB - Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the α integrin genes, ina-1 and pat-2. Utilizing vab-3 mutants, we show that the down-regulation of ina-1 is necessary for DTC migration cessation and the up-regulation of pat-2 is required for directionality. These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size.

KW - Cell migration

KW - Integrins

KW - Organogenesis

KW - Pax6

UR - http://www.scopus.com/inward/record.url?scp=34347381114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347381114&partnerID=8YFLogxK

U2 - 10.1101/gad.1534807

DO - 10.1101/gad.1534807

M3 - Article

C2 - 17606640

AN - SCOPUS:34347381114

SN - 0890-9369

VL - 21

SP - 1615

EP - 1620

JO - Genes and Development

JF - Genes and Development

IS - 13

ER -

Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this